mAbs, Volume 16, Issue 1 (2024)

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mAbs, Volume 16, Issue 1 (2024)

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Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches
Mingyue Li, Victor A. Beaumont, Shahajahan Akbar, Hannah Duncan, Arch Creasy, Wenge Wang, Kelly Sackett, Lisa Marzilli, Jason C. Rouse & Hai-Young Kim
Article: 2292688
Published online: 20 Dec 2023
AbstractforComprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Perspectives

Antibodies to watch in 2024
Silvia Crescioli, Hélène Kaplon, Alicia Chenoweth, Lin Wang, Jyothsna Visweswaraiah & Janice M. Reichert
Article: 2297450
Published online: 05 Jan 2024
AbstractforAntibodies to watch in 2024 | Full Text | References | PDF (932.7 KB) | EPUB | Supplemental
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Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function
Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer & Brooke Harmon
Article: 2297451
Published online: 03 Jan 2024
AbstractforTherapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 1729 Views
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Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro
Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith & Anthony Shock
Article: 2300155
Published online: 19 Jan 2024
AbstractforInteractions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 3006 Views
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Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET
Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl & Achim Doerner
Article: 2302386
Published online: 12 Jan 2024
AbstractforEngineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 6238 Views
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Report
Reduction of monoclonal antibody viscosity using interpretable machine learning
Emily K. Makowski, Hsin-Ting Chen, Tiexin Wang, Lina Wu, Jie Huang, Marissa Mock, Patrick Underhill, Emma Pelegri-O’Day, Erick Maglalang, Dwight Winters & Peter M. Tessier
Article: 2303781
Published online: 12 Mar 2024
AbstractforReduction of monoclonal antibody viscosity using interpretable machine learning | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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A tailored lectin microarray for rapid glycan profiling of therapeutic monoclonal antibodies
Shen Luo & Baolin Zhang
Article: 2304268
Published online: 22 Jan 2024
AbstractforA tailored lectin microarray for rapid glycan profiling of therapeutic monoclonal antibodies | Full Text | References | PDF (12.1 MB) | EPUB | Supplemental
  • 2062 Views
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Variable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG1 antibody
Jing Dai, Saeed Izadi, Jonathan Zarzar, Patrick Wu, Angela Oh & Paul J. Carter
Article: 2304282
Published online: 25 Jan 2024
AbstractforVariable domain mutational analysis to probe the molecular mechanisms of high viscosity of an IgG1 antibody | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 4926 Views
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In-situ biophysical characterization of high-concentration protein formulations using wNMR
Jing Song, Marc Taraban, Y. Bruce Yu, Lynn Lu, Pallavi Guha Biswas, Wei Xu, Hanmi Xi, Akhilesh Bhambhani, Guangli Hu & Yongchao Su
Article: 2304624
Published online: 01 Feb 2024
AbstractforIn-situ biophysical characterization of high-concentration protein formulations using wNMR | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 2797 Views
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability
Wei-Ching Liang, Hongkang Xi, Dawei Sun, Luigi D’Ascenzo, Jonathan Zarzar, Nicole Stephens, Ryan Cook, Yinyin Li, Zhengmao Ye, Marissa Matsumoto, Jian Payandeh, Matthieu Masureel & Yan Wu
Article: 2309685
Published online: 14 Feb 2024
AbstractforStructure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Report
CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma
Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho & Kandasamy Hariharan
Article: 2310248
Published online: 13 Feb 2024
AbstractforCC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 2677 Views
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Review

Review Article
Biparatopic antibodies: therapeutic applications and prospects
David L. Niquille, Kyle M. Fitzgerald & Nimish Gera
Article: 2310890
Published online: 04 Mar 2024
AbstractforBiparatopic antibodies: therapeutic applications and prospects | Full Text | References | PDF (1.8 MB) | EPUB
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Report

Report
Electrostatic properties of human germlines and biodistribution of small biologics
Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia & Alessandro Mascioni
Article: 2311991
Published online: 09 Feb 2024
AbstractforElectrostatic properties of human germlines and biodistribution of small biologics | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1492 Views
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Review

Review Article
Facilitating high throughput bispecific antibody production and potential applications within biopharmaceutical discovery workflows
Caitlin Fawcett, Joseph. R. Tickle & Charlotte. H. Coles
Article: 2311992
Published online: 21 Feb 2024
AbstractforFacilitating high throughput bispecific antibody production and potential applications within biopharmaceutical discovery workflows | Full Text | References | PDF (2.2 MB) | EPUB
  • 5742 Views
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Correction

Correction
Correction
Article: 2312050
Published online: 08 Feb 2024
CitationforCorrection | Full Text | PDF (1.1 MB) | EPUB
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Perspectives

Comment
Charge heterogeneity of therapeutic monoclonal antibodies by different cIEF systems: views on the current situation
Alessandro Ascione, Marcello Belfiore, Jaana Vesterinen, Mihaela Buda, Wolf Holtkamp & Francesca Luciani
Article: 2313737
Published online: 08 Feb 2024
AbstractforCharge heterogeneity of therapeutic monoclonal antibodies by different cIEF systems: views on the current situation | Full Text | References | PDF (822.5 KB) | EPUB | Supplemental
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Report

Report
Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers
Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka & Katja Klausz
Article: 2315640
Published online: 19 Feb 2024
AbstractforImpact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 3879 Views
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Production of antibodies and antibody fragments containing non-natural amino acids in Escherichia coli
Jacquelyn Blake-Hedges, Dan Groff, Wilson Foo, Jeffrey Hanson, Elenor Castillo, Miao Wen, Diana Cheung, Mary Rose Masikat, Jian Lu, Young Park, Nina Abi Carlos, Hans Usman, Kevin Fong, Abigail Yu, Sihong Zhou, Joyce Kwong, Cuong Tran, Xiaofan Li, Dawei Yuan, Trevor Hallam & Gang Yin
Article: 2316872
Published online: 21 Feb 2024
AbstractforProduction of antibodies and antibody fragments containing non-natural amino acids in Escherichia coli | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies
Kristina M.J. Aertker, Minu Ravindra Pilvankar, Tobias M. Prass, Michaela Blech, Fabian Higel & Srinath Kasturirangan
Article: 2318817
Published online: 06 Mar 2024
AbstractforExploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Perspectives

Comment
A pivotal decade for bispecific antibodies?
Marlena Surowka & Christian Klein
Article: 2321635
Published online: 11 Mar 2024
AbstractforA pivotal decade for bispecific antibodies? | Full Text | References | PDF (4.3 MB) | EPUB
  • 10638 Views
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Report

Report
Do antibody CDR loops change conformation upon binding?
Chu’nan Liu, Lilian M. Denzler, Oliver E.C. Hood & Andrew C.R. Martin
Article: 2322533
Published online: 13 Mar 2024
AbstractforDo antibody CDR loops change conformation upon binding? | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 5515 Views
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Report
A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy
Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle & Jay M. Short
Article: 2322562
Published online: 06 Mar 2024
AbstractforA novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 4353 Views
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Perspectives

Comment
Improving the integrity and reproducibility of research that uses antibodies: a technical, data sharing, behavioral and policy challenge
M. Biddle, P. Stylianou, M. Rekas, A. Wright, J. Sousa, D. Ruddy, M. I. Stefana, K. Kmiecik, A. Bandrowski, R.A. Kahn, C. Laflamme, E. M. Krockow & H.S. Virk
Article: 2323706
Published online: 06 Mar 2024
AbstractforImproving the integrity and reproducibility of research that uses antibodies: a technical, data sharing, behavioral and policy challenge | Full Text | References | PDF (1.1 MB) | EPUB
  • 1686 Views
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Report

Report
Application of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies
Armin Sepp & Morris Muliaditan
Article: 2324485
Published online: 04 Mar 2024
AbstractforApplication of quantitative protein mass spectrometric data in the early predictive analysis of membrane-bound target engagement by monoclonal antibodies | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Meeting Report

Meeting Report
Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals
Sophie Tourdot, Daniel Baltrunkonis, Sofie Denies, Viswanath Devanarayan, Joanna Grudzinska-Goebel, Arno Kromminga, Gregor P. Lotz, Laurent Malherbe, Lydia Michaut, Karin N. Weldingh, Joao A. Pedras-Vasconcelos, Laura. I. Salazar-Fontana, Sebastian Spindeldreher, Zuben Sauna, Veerle Snoeck, Daniela Verthelyi & Daniel Kramer
Article: 2324801
Published online: 05 Mar 2024
AbstractforProceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals | Full Text | References | PDF (290.5 KB) | EPUB
  • 2003 Views
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Review

Review Article
T and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics
Ruoxuan Sun, Mark G. Qian & Xiaobin Zhang
Article: 2324836
Published online: 21 Mar 2024
AbstractforT and B cell epitope analysis for the immunogenicity evaluation and mitigation of antibody-based therapeutics | Full Text | References | PDF (1.3 MB) | EPUB
  • 4979 Views
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Report

Report
Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces
W. van der Wulp, W. Luu, M. E. Ressing, J. Schuurman, S. I. van Kasteren, L. Guelen, R. C. Hoeben, B. Bleijlevens & M. H. M. Heemskerk
Article: 2329321
Published online: 18 Mar 2024
AbstractforAntibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 1724 Views
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Report
RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties
Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny & Laura von Schantz
Article: 2330113
Published online: 25 Mar 2024
AbstractforRUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 4035 Views
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Report
Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches
David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick & Giuseppe Licari
Article: 2333436
Published online: 28 Mar 2024
AbstractforPredicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 3763 Views
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Commentary and Views

Comment
In silico methods for immunogenicity risk assessment and human homology screening for therapeutic antibodies
Aimee E. Mattei, Andres H. Gutierrez, Soorya Seshadri, Jacob Tivin, Matt Ardito, Amy S. Rosenberg, William D. Martin & Anne S. De Groot
Article: 2333729
Published online: 27 Mar 2024
AbstractforIn silico methods for immunogenicity risk assessment and human homology screening for therapeutic antibodies | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 5056 Views
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Report

Report
Evaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry
Jing Xu, John E. Coughlin, Malgorzata Szyjka, Serene Jabary, Sonal Saluja, Zoran Sosic, Yunqiu Chen & Chong-Feng Xu
Article: 2334783
Published online: 27 Mar 2024
AbstractforEvaluation of the impact of antibody fragments on aggregation of intact molecules via size exclusion chromatography coupled with native mass spectrometry | Full Text | References | PDF (8 MB) | EPUB | Supplemental
  • 2339 Views
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Correction

Correction
Correction
Article: 2335597
Published online: 28 Mar 2024
CitationforCorrection | Full Text | PDF (3.5 MB) | EPUB
  • 442 Views
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Report

Report
Enrichment strategy and initial characterization of heterodimers enriched from a co-formulated cocktail of therapeutic antibodies against SARS-COV-2
Sophia Liu, Yuetian Yan, Cody M. Secor, Zachary R. Oberholtzer, Donna J. Skow, Mushhood Sheikh, Youmi Moon, Yue Fu, Cristinel Sandu, Shunhai Wang, Ning Li, Jennifer B. Nguyen, Michael P. Rosconi & Erica A. Pyles
Article: 2338301
Published online: 09 Apr 2024
AbstractforEnrichment strategy and initial characterization of heterodimers enriched from a co-formulated cocktail of therapeutic antibodies against SARS-COV-2 | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 1254 Views
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Report
Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody
Eva Schlein, Ken G. Andersson, Tiffany Dallas, Stina Syvänen & Dag Sehlin
Article: 2339337
Published online: 18 Apr 2024
AbstractforReducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody | Full Text | References | PDF (3.1 MB) | EPUB
  • 2848 Views
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Report
Antibody association in solution: cluster distributions and mechanisms
Sandi Brudar, Leonid Breydo, Elisha Chung, Ken A. Dill, Nasim Ehterami, Ketan Phadnis, Samir Senapati, Mohammed Shameem, Xiaolin Tang, Muhammmad Tayyab & Barbara Hribar-Lee
Article: 2339582
Published online: 26 Apr 2024
AbstractforAntibody association in solution: cluster distributions and mechanisms | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1879 Views
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Review

Review Article
Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions
Michael Mullin, James McClory, Winston Haynes, Justin Grace, Nathan Robertson & Gino van Heeke
Article: 2341443
Published online: 26 Apr 2024
AbstractforApplications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions | Full Text | References | PDF (3.3 MB) | EPUB
  • 9045 Views
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Report

Report
Targeted CQA analytical control strategy for commercial antibody products: Replacing ion-exchange chromatography methods for charge heterogeneity with multi-attribute monitoring
Adam R. Evans, Joseph Mulholland, Michael J. Lewis & Ping Hu
Article: 2341641
Published online: 23 Apr 2024
AbstractforTargeted CQA analytical control strategy for commercial antibody products: Replacing ion-exchange chromatography methods for charge heterogeneity with multi-attribute monitoring | Full Text | References | PDF (948.3 KB) | EPUB | Supplemental
  • 2377 Views
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Report
Alternative splicing for tuneable expression of protein subunits at desired ratios
Christel Aebischer-Gumy, Pierre Moretti, Timothee Brunstein Laplace, Jana Frank, Ysaline Grand, Farid Mosbaoui, Emilie Hily, Anna Galea, Megane Peltret, Carole Estoppey, Daniel Ayoub, Roberto Giovannini & Martin Bertschinger
Article: 2342243
Published online: 22 Apr 2024
AbstractforAlternative splicing for tuneable expression of protein subunits at desired ratios | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 1163 Views
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Review

Review Article
Can antibodies be “vegan”? A guide through the maze of today’s antibody generation methods
Stefan Dübel
Article: 2343499
Published online: 18 Apr 2024
AbstractforCan antibodies be “vegan”? A guide through the maze of today’s antibody generation methods | Full Text | References | PDF (2 MB) | EPUB
  • 2560 Views
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Report

Report
Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach
Ronghua Bei, Justin Thomas, Shiven Kapur, Mahlet Woldeyes, Adam Rauk, Jason Robarge, Jiangyan Feng & Kaoutar Abbou Oucherif
Article: 2352887
Published online: 14 May 2024
AbstractforPredicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
  • 2998 Views
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Correction

Correction
Correction
Article: 2354626
Published online: 12 May 2024
CitationforCorrection | Full Text | PDF (585.2 KB) | EPUB
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Report

Report
Insight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn
Johannes Reusch, Jan Terje Andersen, Ulrich Rant & Tilman Schlothauer
Article: 2361585
Published online: 07 Jun 2024
AbstractforInsight into the avidity–affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 3100 Views
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Report
Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery
Pawel Dudzic, Dawid Chomicz, Jarosław Kończak, Tadeusz Satława, Bartosz Janusz, Sonia Wrobel, Tomasz Gawłowski, Igor Jaszczyszyn, Weronika Bielska, Samuel Demharter, Roberto Spreafico, Lukas Schulte, Kyle Martin, Stephen R. Comeau & Konrad Krawczyk
Article: 2361928
Published online: 06 Jun 2024
AbstractforLarge-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery | Full Text | References | PDF (1.9 MB) | EPUB
  • 2566 Views
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Report
Structural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1
Pauline Malinge, Xavier Chauchet, Jérémie Bourguignon, Nicolas Bosson, Sébastien Calloud, Tereza Bautzova, Marie Borlet, Mette Laursen, Vinardas Kelpsas, Nadia Rose, Franck Gueneau, Ulla Ravn, Giovanni Magistrelli & Nicolas Fischer
Article: 2362432
Published online: 07 Jun 2024
AbstractforStructural analysis of light chain-driven bispecific antibodies targeting CD47 and PD-L1 | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 1688 Views
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Report
Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen
Mark Hutchinson, Jeffrey A. Ruffolo, Nantaporn Haskins, Michael Iannotti, Giuliana Vozza, Tony Pham, Nurjahan Mehzabeen, Harini Shandilya, Keith Rickert, Rebecca Croasdale-Wood, Melissa Damschroder, Ying Fu, Andrew Dippel, Jeffrey J. Gray & Gilad Kaplan
Article: 2362775
Published online: 20 Jun 2024
AbstractforToward enhancement of antibody thermostability and affinity by computational design in the absence of antigen | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 3919 Views
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Report
Molecular surface descriptors to predict antibody developability: sensitivity to parameters, structure models, and conformational sampling
Eliott Park & Saeed Izadi
Article: 2362788
Published online: 10 Jun 2024
AbstractforMolecular surface descriptors to predict antibody developability: sensitivity to parameters, structure models, and conformational sampling | Full Text | References | PDF (7.4 MB) | EPUB | Supplemental
  • 5022 Views
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Report
Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies
Wen-Ting K. Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen & Paul J. Carter
Article: 2362789
Published online: 06 Jun 2024
AbstractforNonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG1 antibodies | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 5133 Views
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Correction

Correction
Correction
Article: 2364972
Published online: 07 Jun 2024
CitationforCorrection | Full Text | PDF (888.5 KB) | EPUB
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Report

Report
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li & Timothy A. Springer
Article: 2365891
Published online: 18 Jun 2024
AbstractforSynthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 1147 Views
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Report
Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy
Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy & Brian Kuhlman
Article: 2373325
Published online: 04 Jul 2024
AbstractforEngineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 4611 Views
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Comment

Comment
The history and potential future of monoclonal antibody therapeutics development and manufacturing in four eras
Brian Kelley
Article: 2373330
Published online: 01 Jul 2024
AbstractforThe history and potential future of monoclonal antibody therapeutics development and manufacturing in four eras | Full Text | References | PDF (215.3 KB) | EPUB
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Report
Early determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity assessment
Shuai Wang, Yanqiu Wang, Zhenzhen Li, Ye Hong, Zhaohui Wang, Jiteng Fan, Qiong Wang, Yuanjie Ge, Xiaofeng Zhao, Guangcun Cheng, Changyan Chen, Yadan Wu & Yayuan Fu
Article: 2374607
Published online: 02 Jul 2024
AbstractforEarly determination of potential critical quality attributes of therapeutic antibodies in developability studies through surface plasmon resonance-based relative binding activity assessment | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations
Melanie Maier, Linus Weiß, Nikolas Zeh, Valerie Schmieder-Todtenhaupt, Alireza Dehghani, Marius Nicolaus Felix, Daniel Heinzelmann, Benjamin Lindner, Moritz Schmidt, Joey Studts, Patrick Schulz, Bernd Reisinger, Kerstin Otte, Matthias Franzreb, Daniel Lakatos & Simon Fischer
Article: 2375798
Published online: 10 Jul 2024
AbstractforIlluminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 1793 Views
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Modulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations
Joel Heisler, Daniel Kovner, Saeed Izadi, Jonathan Zarzar & Paul J. Carter
Article: 2379560
Published online: 19 Jul 2024
AbstractforModulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Brief Report

Brief Report
Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay
Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei & Mark G. Qian
Article: 2379903
Published online: 30 Jul 2024
AbstractforQuantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay | Full Text | References | PDF (1.1 MB) | EPUB
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Report

Report
Identification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers
Bill Liao, Christine Tumanut, Lin Li, Adam Corper, Dilip Challa, Alex Chang, Hydari Begum, Elinaz Farokhi, Catherine Woods & Xiaomin Fan
Article: 2381261
Published online: 24 Jul 2024
AbstractforIdentification of novel anti-CD16a antibody clones for the development of effective natural killer cell engagers | Full Text | References | PDF (6 MB) | EPUB | Supplemental
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy
Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis & Christoph Huber
Article: 2381891
Published online: 23 Jul 2024
AbstractforDiscovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Rapid depletion of “catch-and-release” anti-ASGR1 antibody in vivo
Siva Charan Devanaboyina, Peng Li, Edward L. LaGory, Carrie Poon-Andersen, Kevin D. Cook, Marcus Soto, Zhe Wang, Khue Dang, Craig Uyeda, Ryan B. Case, Veena A. Thomas, Ronya Primack, Manuel Ponce, Mei Di, Brian Ouyang, Joelle Kaner, Sheung Kwan Lam & Mina Mostafavi
Article: 2383013
Published online: 25 Jul 2024
AbstractforRapid depletion of “catch-and-release” anti-ASGR1 antibody in vivo | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Assessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows
Tushar Jain, Bianka Prinz, Alexander Marker, Alexander Michel, Katrin Reichel, Valerie Czepczor, Sylvie Klieber, Wei Sun, Sagar Kathuria, Sevim Oezguer Bruederle, Christian Lange, Lena Wahl, Charles Starr, Alessandro Masiero & Lindsay Avery
Article: 2384104
Published online: 31 Jul 2024
AbstractforAssessment and incorporation of in vitro correlates to pharmacokinetic outcomes in antibody developability workflows | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Report
Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer
Xiaojie Chu, Seungmin Shin, Du-San Baek, Liyong Zhang, Alex Conard, Megan Shi, Ye-Jin Kim, Cynthia Adams, Maggie Hines, Xianglei Liu, Chuan Chen, Zehua Sun, Dontcho V. Jelev, John W. Mellors, Dimiter S. Dimitrov & Wei Li
Article: 2387240
Published online: 08 Aug 2024
AbstractforDiscovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Review

Review Article
The emergence of cell-based protein arrays to test for polyspecific off-target binding of antibody therapeutics
Diana M. Norden, Carmen T. Navia, Jonathan T. Sullivan & Benjamin J. Doranz
Article: 2393785
Published online: 24 Aug 2024
AbstractforThe emergence of cell-based protein arrays to test for polyspecific off-target binding of antibody therapeutics | Full Text | References | PDF (3.8 MB) | EPUB
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Review Article
Developability considerations for bispecific and multispecific antibodies
Alaa Amash, Gesa Volkers, Patrick Farber, Daniel Griffin, K. Shawn Davison, Allison Goodman, Raffi Tonikian, Aaron Yamniuk, Bryan Barnhart & Tim Jacobs
Article: 2394229
Published online: 27 Aug 2024
AbstractforDevelopability considerations for bispecific and multispecific antibodies | Full Text | References | PDF (805.2 KB) | EPUB
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Report

Report
A next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability
Fortunato Ferrara, Adeline Fanni, Andre A. R. Teixeira, Esteban Molina, Camila Leal-Lopes, Ashley DeAguero, Sara D’Angelo, M. Frank Erasmus, Laura Spector, Luis Antonio Rodriguez Carnero, Jianquan Li, Thomas J. Pohl, Nikolai Suslov, Klervi Desrumeaux, Conor McMahon, Sagar Kathuria & Andrew R. M. Bradbury
Article: 2394230
Published online: 27 Aug 2024
AbstractforA next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 2914 Views
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Report
IL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release
John S. Schardt, Even Walseng, Kim Le, Chunning Yang, Pooja Shah, Ying Fu, Kausar Alam, Cathryn R. Kelton, Yu Gu, Fengying Huang, Jia Lin, Wenhai Liu, Andrew Dippel, Hanzhi Zhang, Kathy Mulgrew, Stacy Pryts, Vijaykumar Chennupati, Hung-Chang Chen, Jessica Denham, Xiaoru Chen, Pallab Pradhan, Yuling Wu, Colin Hardman, Chihao Zhao, Michael Kierny, Yang Song, Simon J. Dovedi, Saso Cemerski & Yariv Mazor
Article: 2395499
Published online: 28 Aug 2024
AbstractforIL-2-armored peptide-major histocompatibility class I bispecific antibodies redirect antiviral effector memory CD8+ T cells to induce potent anti-cancer cytotoxic activity with limited cytokine release | Full Text | References | PDF (5 MB) | EPUB | Supplemental
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Report
Expanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry
Yutian Gan, Steffen Lippold, John Stobaugh, Christian Schöneich & Feng Yang
Article: 2395503
Published online: 27 Aug 2024
AbstractforExpanding the structural resolution of glycosylation microheterogeneity in therapeutic proteins by salt-free hydrophilic interaction liquid chromatography tandem mass spectrometry | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 1634 Views
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Report
Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing
Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker & Fabian Higel
Article: 2400414
Published online: 08 Sep 2024
AbstractforDecoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 1753 Views
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Brief Report

Brief Report
Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors
Geoff Hale, Jelle De Vos, Alastair Douglas Davy, Koen Sandra & Ian Wilkinson
Article: 2402701
Published online: 15 Sep 2024
AbstractforSystematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 10525 Views
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Review

Review Article
Navigating large-volume subcutaneous injections of biopharmaceuticals: a systematic review of clinical pipelines and approved products
Philip Green, Andreas Schneider & Jakob Lange
Article: 2402713
Published online: 15 Sep 2024
AbstractforNavigating large-volume subcutaneous injections of biopharmaceuticals: a systematic review of clinical pipelines and approved products | Full Text | References | PDF (3.6 MB) | EPUB
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Report

Report
A comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs
Itzel Condado-Morales, Fabian Dingfelder, Isabel Waibel, Oliver M. Turnbull, Bhargav Patel, Zheng Cao, Jais Rose Bjelke, Susanne Nedergaard Grell, Anja Bennet, Alissa M. Hummer, Matthew I. J. Raybould, Charlotte M. Deane, Thomas Egebjerg, Nikolai Lorenzen & Paolo Arosio
Article: 2403156
Published online: 04 Oct 2024
AbstractforA comparative study of the developability of full-length antibodies, fragments, and bispecific formats reveals higher stability risks for engineered constructs | Full Text | References | PDF (5.5 MB) | Supplemental
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Sequence-based engineering of pH-sensitive antibodies for tumor targeting or endosomal recycling applications
Wanlei Wei & Traian Sulea
Article: 2404064
Published online: 17 Sep 2024
AbstractforSequence-based engineering of pH-sensitive antibodies for tumor targeting or endosomal recycling applications | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 2557 Views
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Brief Report

Brief Report
Systematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors
Geoff Hale, Alastair Douglas Davy & Ian Wilkinson
Article: 2406539
Published online: 22 Sep 2024
AbstractforSystematic analysis of Fc mutations designed to enhance binding to Fc-gamma receptors | Full Text | References | PDF (1 MB) | EPUB
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Report

Report
Discovery of potent allosteric antibodies inhibiting EGFR
Léxane Fournier, Lukas Pekar, Birgitta Leuthner, Harald Kolmar, Lars Toleikis & Stefan Becker
Article: 2406548
Published online: 20 Sep 2024
AbstractforDiscovery of potent allosteric antibodies inhibiting EGFR | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Report
FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques
Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha & Diogo M. Magnani
Article: 2406788
Published online: 26 Sep 2024
AbstractforFcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques | Full Text | References | PDF (8.4 MB) | Supplemental
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Report
Seq2scFv: a toolkit for the comprehensive analysis of display libraries from long-read sequencing platforms
Marianne Bachmann Salvy, Luca Santuari, Emanuel Schmid-Siegert, Nikolaos Lykoskoufis, Ioannis Xenarios & Bulak Arpat
Article: 2408344
Published online: 08 Oct 2024
AbstractforSeq2scFv: a toolkit for the comprehensive analysis of display libraries from long-read sequencing platforms | Full Text | References | PDF (2.1 MB) | Supplemental
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Report
CD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody
Cristina Melero, S. Jimmy Budiardjo, Anahita Daruwalla, Lance Larrabee, Oleg Ganichkin, Alexander J. Heiler, Jill Fenaux, Ben Chung, Germaine Fuh & Yao-Ming Huang
Article: 2410316
Published online: 14 Oct 2024
AbstractforCD200R1 immune checkpoint blockade by the first-in-human anti-CD200R1 antibody 23ME-00610: molecular mechanism and engineering of a surrogate antibody | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β
Rebecca Faresjö, Elisabet O. Sjöström, Tiffany Dallas, Magnus M. Berglund, Jonas Eriksson, Dag Sehlin & Stina Syvänen
Article: 2410968
Published online: 02 Oct 2024
AbstractforSingle domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β | Full Text | References | PDF (4.3 MB) | Supplemental
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Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo
Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng & Qing Xu
Article: 2412881
Published online: 09 Oct 2024
AbstractforAnti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration
Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen & Jeffrey Hunter
Article: 2415060
Published online: 13 Oct 2024
AbstractforCharacterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Report
Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan
Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park & Qun Zhou
Article: 2415333
Published online: 21 Oct 2024
AbstractforTargeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Correction

Correction
Correction
Article: 2416272
Published online: 20 Oct 2024
CitationforCorrection | Full Text | PDF (178.8 KB) | EPUB
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Report

Report
GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models
Yu Huang, Jinyong Wang, Xiling Wei, Hui Zhang, Wei Shang, Xiangling Zhang, Lanjiao Zhai, Xi Chen, Huiming Li & Suofu Qin
Article: 2416453
Published online: 14 Oct 2024
AbstractforGB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies
Yizhou Zhang, Ruicheng Wei, Ge Song, Xinyi Yang, Mengli Zhang, Wei Liu, Aiying Xiong, Xuehan Zhang, Qianhao Li, Wan-Jen Yang, Chencheng Han, Rui Liu, Chen Hu, Qingyu Wang, Jun Zhu & Yongqiang Shan
Article: 2419838
Published online: 04 Nov 2024
AbstractforInsights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies | Full Text | References | PDF (5.7 MB) | Supplemental
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Practical solutions for overcoming artificial disulfide scrambling in the non-reduced peptide mapping characterization of monoclonal antibodies
Andrew Kleinberg, Yuan Mao & Ning Li
Article: 2420805
Published online: 26 Oct 2024
AbstractforPractical solutions for overcoming artificial disulfide scrambling in the non-reduced peptide mapping characterization of monoclonal antibodies | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Understanding the impacts of dual methionine oxidations in complementarity-determining regions on the structure of monoclonal antibodies
Bo Zhao, Joy Yoon, Bojie Zhang, Youmi Moon, Yue Fu, Yinyin Li, Yunlong Zhao, Hui Xiao & Ning Li
Article: 2422898
Published online: 02 Nov 2024
AbstractforUnderstanding the impacts of dual methionine oxidations in complementarity-determining regions on the structure of monoclonal antibodies | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Residue-resolved insights into the stabilization of therapeutic proteins by excipients: A case study of two monoclonal antibodies with arginine and glutamate
Tobias M. Prass, Patrick Garidel, Lars V. Schäfer & Michaela Blech
Article: 2427771
Published online: 14 Nov 2024
AbstractforResidue-resolved insights into the stabilization of therapeutic proteins by excipients: A case study of two monoclonal antibodies with arginine and glutamate | Full Text | References | PDF (9.8 MB) | EPUB | Supplemental
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Development of a novel, high-throughput imaged capillary isoelectric focusing-Western method to characterize charge heterogeneity of monoclonal antibody heavy and light chains
Gangadhar Dhulipala, Alanna Broszeit, Kun Lu, Nisha Palackal & Erica Pyles
Article: 2429414
Published online: 15 Nov 2024
AbstractforDevelopment of a novel, high-throughput imaged capillary isoelectric focusing-Western method to characterize charge heterogeneity of monoclonal antibody heavy and light chains | Full Text | References | PDF (869.2 KB) | EPUB
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Multivariate quantitative analysis of glycan impact on IgG1 effector functions
Tamara Cvijić, Matej Horvat, Jakob Plahutnik, Ana Golob & Jaka Marušič
Article: 2430295
Published online: 21 Nov 2024
AbstractforMultivariate quantitative analysis of glycan impact on IgG1 effector functions | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings
Maria Meira, Aurore Frey, Neila Chekkat, Magda Rybczynska, Zaki Sellam, Joon Seok Park, Francesca Smylie Gazzaniga, Alexia Parmentier, Marianne Le Gall, Gordon James Freeman, Dennis Lee Kasper, Arlene Helen Sharpe, Eric Rambeaux & Abdijapar Shamshiev
Article: 2432403
Published online: 26 Nov 2024
AbstractforTargeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Agonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands
Daniel Fallon, Ching-Shin Huang, Jingya Ma, Christopher Morgan & Zhaohui Sunny Zhou
Article: 2433121
Published online: 25 Nov 2024
AbstractforAgonistic anti-NKG2D antibody structure reveals unique stoichiometry and epitope compared to natural ligands | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Humatch - fast, gene-specific joint humanisation of antibody heavy and light chains
Lewis Chinery, Jeliazko R. Jeliazkov & Charlotte M. Deane
Article: 2434121
Published online: 29 Nov 2024
AbstractforHumatch - fast, gene-specific joint humanisation of antibody heavy and light chains | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery
Christine N. Vuong, Kevin M. Reynolds, Gerry S. Rivera, Baisen Zeng, Zahra Karimpourkalou, Manith Norng, Yulei Zhang, Robayet Chowdhury, Darlene Pedersen, Melissa Pantoja, Ellen Collarini, Swetha Garimalla, Shelley Izquierdo, Eric G. Vajda, Brett Antonio, Devendra B. Srivastava, Marie-Cecile van de Lavoir, Yasmina Abdiche, William Harriman & Philip A. Leighton
Article: 2435476
Published online: 28 Nov 2024
AbstractforHeavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discovery | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Coactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia
Byungtae Hwang, Min-Young Jeon, Ju-Hong Jang, Young-Lai Cho, Dong Gwang Lee, Jeong-Ki Min, Jangwook Lee, Jong-Gil Park, Ji-Hun Noh, Wonjun Yang & Nam-Kyung Lee
Article: 2435478
Published online: 28 Nov 2024
AbstractforCoactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Correction

Correction
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Article: 2436775
Published online: 04 Dec 2024
CitationforCorrection | Full Text | PDF (779 KB) | EPUB
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Report

Report
Reconciling predicted and measured viscosity parameters in high concentration therapeutic antibody solutions
Georgina Bethany Armstrong, Aisling Roche, William Lewis & Zahra Rattray
Article: 2438172
Published online: 11 Dec 2024
AbstractforReconciling predicted and measured viscosity parameters in high concentration therapeutic antibody solutions | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer
Peter Jung, Stefan P. Glaser, Jing Han, Alexandra Popa, Laura Pisarsky, Ningping Feng, Antonia Geyer, Franziska Haderk, Donat Alpar, Christopher Bristow, Susanne Schmittner, Paula-Elena Traexler, Mikhila Mahendra, Birgit Poehn, Poojabahen Gandhi, Roberto Fiorelli, Sanket Awate, Nicole Budano, Florian Martin, Christoph Albrecht, Barbara Drobits-Handl, Sathanandam S. Anand, Srinath Kasturirangan, Francesca Trapani, Norbert Schweifer, Joseph R. Marszalek, Ulrike Tontsch-Grunt, Mark Pearson, Timothy P. Heffernan, Norbert Kraut, Christopher P. Vellano & Juan Manuel García-Martínez
Article: 2438173
Published online: 09 Dec 2024
AbstractforA TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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