Autophagy, Volume 21, Issue 5 (2025)

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Autophagy, Volume 21, Issue 5 (2025)

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Editor’s Corner

Editorial
The emerging significance of Vac8, a multi-purpose armadillo-repeat protein in yeast
Hana Popelka & Daniel J. Klionsky
Pages: 913-916
Published online: 24 Jul 2024
AbstractforThe emerging significance of Vac8, a multi-purpose armadillo-repeat protein in yeast | Full Text | References | PDF (762.5 KB) | EPUB
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Free Access

Research Paper

Article
Baicalein tethers CD274/PD-L1 for autophagic degradation to boost antitumor immunity
Bingjie Hao, Shumeng Lin, Haipeng Liu, Junfang Xu, Li Chen, Tiansheng Zheng, Wen Zhang, Yifang Dang, Russel J. Reiter, Chaoqun Li, Hong Zhai, Qing Xia & Lihong Fan
Pages: 917-933
Published online: 22 Dec 2024
AbstractforBaicalein tethers CD274/PD-L1 for autophagic degradation to boost antitumor immunity | Full Text | References | PDF (6.5 MB) | EPUB | Supplemental
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Research paper

Article
Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death
Karla Alvarez-Valadez, Allan Sauvat, Julien Diharce, Marion Leduc, Gautier Stoll, Lionel Guittat, Flavia Lambertucci, Juliette Paillet, Omar Motiño, Lucille Ferret, Alexandra Muller, Sabrina Forveille, Maria Chiara Maiuri, Oliver Kepp, Alexandre G de Brevern, Harald Wodrich, Jonathan G Pol, Guido Kroemer & Mojgan Djavaheri-Mergny
Pages: 934-956
Published online: 27 Dec 2024
AbstractforLysosomal damage due to cholesterol accumulation triggers immunogenic cell death | Full Text | References | PDF (8.8 MB) | EPUB | Supplemental
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Article
Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy
Isabel Gordaliza-Alaguero, Paula Sànchez-Fernàndez-de-Landa, Dragana Radivojevikj, Laura Villarreal, Gianluca Arauz-Garofalo, Marina Gay, Marta Martinez-Vicente, Jorge Seco, Pau Martín-Malpartida, Marta Vilaseca, María J. Macías, Manuel Palacin, Saška Ivanova & Antonio Zorzano
Pages: 957-978
Published online: 24 Dec 2024
AbstractforEndogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 1300 Views
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Article
Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration
Sheng Liu, Yiqiang Hu, Weihua Xu, Weijian Liu, Bingjin Wang, Xianlin Zeng, Zengwu Shao, Cao Yang, Liming Xiong & Xianyi Cai
Pages: 979-995
Published online: 25 Dec 2024
AbstractforRestoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration | Full Text | References | PDF (9.1 MB) | EPUB | Supplemental
  • 634 Views
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Research Paper

Article
The Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy
Jiangnan Liu, Noemi Nagy, Carlos Ayala-Torres, Solenne Bleuse, Francisco Aguilar-Alonso, Ola Larsson & Maria G. Masucci
Pages: 996-1018
Published online: 22 Jan 2025
AbstractforThe Epstein-Barr virus deubiquitinase BPLF1 regulates stress-induced ribosome UFMylation and reticulophagy | Full Text | References | PDF (4 MB) | EPUB | Supplemental
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Open Access
Article
Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase
Carlos Ayala-Torres, Jiangnan Liu, Nico P. Dantuma & Maria G. Masucci
Pages: 1019-1038
Published online: 02 Jan 2025
AbstractforRegulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Open Access
Article
Drosophila aux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation
Shiping Zhang, Linfang Wang, Shuanglong Yi, Yu-Ting Tsai, Yi-Hsuan Cheng, Yu-Tung Lin, Chia-Ching Lin, Yi-Hua Lee, Honglei Wang, Shuhua Li, Ruiqi Wang, Yang Liu, Wei Yan, Chang Liu, Kai-Wen He & Margaret S. Ho
Pages: 1039-1058
Published online: 29 Jan 2025
AbstractforDrosophila aux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/α-synuclein degradation | Full Text | References | PDF (7.3 MB) | EPUB | Supplemental
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Open Access
Article
Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation
Van Bui, Xinwen Liang, Yansheng Ye, William Giang, Fang Tian, Yoshinori Takahashi & Hong-Gang Wang
Pages: 1059-1074
Published online: 20 Jan 2025
AbstractforBlocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
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Open Access

Research paper

Article
Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival
Laura Zein, Marvin Dietrich, Denise Balta, Verian Bader, Christoph Scheuer, Suzanne Zellner, Nadine Weinelt, Julia Vandrey, Muriel C. Mari, Christian Behrends, Friederike Zunke, Konstanze F. Winklhofer & Sjoerd J. L. Van Wijk
Pages: 1075-1095
Published online: 02 Jan 2025
AbstractforLinear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival | Full Text | References | PDF (6 MB) | EPUB | Supplemental
  • 1877 Views
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Research Paper

Article
The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease
Hongtao Shen, Yuying Xie, Yan Wang, Yusheng Xie, Yongxiang Wang, Zhenyan Su, Laixi Zhao, Shi Yao, Xiaoling Cao, Jinglan Liang, Junrui Long, Rimei Zhong, Jinfeng Tang, Sijie Wang, Liangqing Zhang, Xiaojing Wang, Björn Stork, Lili Cui & Wenxian Wu
Pages: 1096-1115
Published online: 15 Jan 2025
AbstractforThe ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
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Translational research paper

Article
Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in Charcot-Marie-Tooth type 2 neuropathies
Angela Sisto, Tamira van Wermeskerken, Michael Pancher, Pamela Gatto, Bob Asselbergh, Ágata Sofia Assunção Carreira, Vicky De Winter, Valentina Adami, Alessandro Provenzani & Vincent Timmerman
Pages: 1116-1143
Published online: 27 Dec 2024
AbstractforAutophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in Charcot-Marie-Tooth type 2 neuropathies | Full Text | References | PDF (8.7 MB) | EPUB | Supplemental
  • 2067 Views
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Open Access

Resource

Article
Development and validation of a sensitive sandwich ELISA against human PINK1
Zahra Baninameh, Jens O. Watzlawik, Bernardo A. Bustillos, Gabriella Fiorino, Tingxiang Yan, Szymon L. Lewicki, Haonan Zhang, Dennis W. Dickson, Joanna Siuda, Zbigniew K. Wszolek, Wolfdieter Springer & Fabienne C. Fiesel
Pages: 1144-1159
Published online: 06 Feb 2025
AbstractforDevelopment and validation of a sensitive sandwich ELISA against human PINK1 | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1285 Views
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Open Access

Autophagic Punctum

Article Commentary
Rubicon regulates exosome secretion via the non-autophagic pathway
Kyosuke Yanagawa & Tamotsu Yoshimori
Pages: 1160-1162
Published online: 12 Dec 2024
AbstractforRubicon regulates exosome secretion via the non-autophagic pathway | Full Text | References | PDF (544.9 KB) | EPUB
  • 346 Views
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Article Commentary
Induction of lysosome biogenesis is a novel function of the CGAS-STING1 pathway
Yinfeng Xu & Wei Wan
Pages: 1163-1164
Published online: 27 Jan 2025
AbstractforInduction of lysosome biogenesis is a novel function of the CGAS-STING1 pathway | Full Text | References | PDF (203.7 KB) | EPUB
  • 571 Views
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Article Commentary
Chaperone-mediated autophagy contributes to chromosomal stability by controlling TTC28 degradation
Ge Zhang, Wei Tian & Dajun Deng
Pages: 1165-1166
Published online: 07 Feb 2025
AbstractforChaperone-mediated autophagy contributes to chromosomal stability by controlling TTC28 degradation | Full Text | References | PDF (577.6 KB) | EPUB
  • 211 Views
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Article Commentary
Flavivirus NS2A orchestrates reticulophagy to enhance viral pathogenicity
Linliang Zhang, Yali Qin & Mingzhou Chen
Pages: 1167-1168
Published online: 07 Feb 2025
AbstractforFlavivirus NS2A orchestrates reticulophagy to enhance viral pathogenicity | Full Text | References | PDF (331 KB) | EPUB
  • 376 Views
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Article Commentary
Quality control of ABCD3 by the VCP-FAF2 complex suppresses excessive pexophagy
Fumika Koyano & Noriyuki Matsuda
Pages: 1169-1170
Published online: 10 Feb 2025
AbstractforQuality control of ABCD3 by the VCP-FAF2 complex suppresses excessive pexophagy | Full Text | References | PDF (352.7 KB) | EPUB
  • 872 Views
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Open Access

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