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Nucleosides, Nucleotides & Nucleic Acids

Volume 23, 2004 - Issue 1-2
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Original Articles

Inhibitors of Adenosine Deaminase: Continued Studies of Structure‐Activity Relationships in Analogues of Coformycin

Ayub Reayi Laboratory for Drug Design and Synthesis , Department of Chemistry and Biochemistry , University of Maryland, Baltimore County , 1000 Hilltop Circle, Baltimore, Maryland, 21250, USA
&
Ramachandra S. Hosmane Laboratory for Drug Design and Synthesis , Department of Chemistry and Biochemistry , University of Maryland, Baltimore County , 1000 Hilltop Circle, Baltimore, Maryland, 21250, USA Correspondencehosmane@umbc.edu
Pages 263-271
Received 08 Aug 2003
Accepted 14 Oct 2003
Published online: 01 Jun 2007
 
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Abstract

Synthesis and adenosine deaminase (ADA) inhibitory activity of two analogues of coformycin, containing the imidazo[4,5‐e][1,2,4]triazepine ring system, have been reported as part of the structure‐activity relationship (SAR) studies to explore the factors responsible for the extremely tight‐binding characteristics of coformycins to ADA.

Acknowledgments

This research was supported by a grant (#9 RO1 AI55452) from the National Institutes of Health. Authors thank Dr. Diana S. Hamilton for advice regarding the reported enzyme kinetics studies.

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