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Research Articles

Chronic fatigue syndrome versus systemic exertion intolerance disease

, , , , &
Pages 127-141
Received 13 Mar 2015
Accepted 11 May 2015
Published online: 15 Jun 2015
 

Background: The Institute of Medicine has recommended a change in the name and criteria for chronic fatigue syndrome (CFS), renaming the illness systemic exertion intolerance disease (SEID). The new SEID case definition requires substantial reductions or impairments in the ability to engage in pre-illness activities, unrefreshing sleep, post-exertional malaise, and either cognitive impairment or orthostatic intolerance. Purpose: In the current study, samples were generated through several different methods and were used to compare this new case definition to previous case definitions for CFS, the International Consensus Criteria for myalgic encephalomyelitis (ME-ICC), the Canadian myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) definition, as well as a case definition developed through empirical methods. Methods: We used a cross-sectional design with samples from tertiary care settings, a BioBank sample, and other forums. Seven hundred and ninety-six patients from the USA, Great Britain, and Norway completed the DePaul Symptom Questionnaire. Results: Findings indicated that the SEID criteria identified 88% of participants in the samples analyzed, which is comparable to the 92% that met the Fukuda criteria. The SEID case definition was compared to a four-item empiric criteria, and findings indicated that the four-item empiric criteria identified a smaller, more functionally limited and symptomatic group of patients. Conclusion: The recently developed SEID criteria appears to identify a group comparable in size to the Fukuda et al. criteria, but a larger group of patients than the Canadian ME/CFS and ME criteria, and selects more patients who have less impairment and fewer symptoms than a four-item empiric criteria.

Acknowledgments

The authors appreciate the Solve ME/CFS Initiative (formerly the CFIDS Association of America), which approved the use of de-identified Solve CFS BioBank registry data in this analysis.

Additional information

Funding

Funding was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant number R01HD072208).

Notes on contributors

Leonard A. Jason

Leonard A. Jason is the Director of the Center for Community Research and Professor of Psychology at DePaul University.

Madison Sunnquist

Madison Sunnquist is currently a graduate student in the Clinical-Community Psychology doctoral program at DePaul University.

Abigail Brown

Abigail Brown is currently a a graduate student in the Clinical-Community Psychology doctoral program at DePaul University.

Julia L. Newton

Julia L. Newton is the Dean of Clinical Medicine and Clinical Professor of Ageing and Medicine at Newcastle University in the UK.

Elin Bolle Strand

Elin Bolle Strand is the Managing Director at Key IT AS at Oslo University Hospital.

Suzanne D. Vernon

Suzanne D. Vernon is the Scientific Director of the Solve ME/CFS Initiative.

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