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Aspartame (APM) is the most commonly used artificial sweetener and flavor enhancer in the world. There is a rise in concern that APM is carcinogenic due to a variation in the findings of the previous APM carcinogenic bioassays. This article conducts a meta-analytic review of all previous APM carcinogenic bioassays on rodents that were conducted before 31 December 2012. The search yielded 10 original APM carcinogenic bioassays on rodents. The aggregate effect sizes suggest that APM consumption has no significant carcinogenic effect in rodents.
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Acknowledgments
The authors are grateful to Dr Anne Moyer, Associate Professor, Department of Psychology at Stony Brook University, for her valuable suggestions on this analysis, by which this meta-analysis has been substantially improved. They are also grateful to the reviewers for their valuable advice and corrections in the paper.
Studies preceded by an asterisk are included in the meta-analysis.