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Original Articles

Effect of inverting electrode on mismatch negativity presence for perceptible/imperceptible tonal frequency contrasts

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Pages 708-714
Received 30 Aug 2007
Published online: 07 Jul 2009
 

The effect of inverting electrode location and stimulus perceptibility on the presence of the mismatch negativity (MMN) evoked response was investigated in 20 normal-hearing adult females. Perceptible and imperceptible frequency contrasts were employed in an oddball paradigm. The perceptible contrast consisted of an 1122Hz standard and a 1000Hz target, while the imperceptible contrast consisted of an 1122Hz standard and an 1120Hz target. Data were referenced separately to the tip of the nose, the ipsilateral mastoid, and the mathematical average of the two mastoids. Presence of a response was determined according to strict criteria established a priori. The correspondence between MMN findings and parallel behavioral discrimination data was not systematic. Inverting electrode had an effect of MMN presence. MMNs were more likely to be present for mastoid-referenced data than nose-referenced data. Thus, when using the current paradigm, a mastoid reference is suggested to optimize the detection of the MMN response.

Sumario

Se investigó el efecto de invertir la ubicación del electrodo y la perceptibilidad del estímulo sobre la presencia de la respuesta evocada de negatividad dispar (MMN) en 20 mujeres normoyentes. Se utilizaron contrastes frecuenciales perceptibles e imperceptibles en un paradigma inesperado. El contraste perceptible estaba constituido por 1122Hz como estándar y 1000Hz como objetivo, mientras que el contraste imperceptible contenía 1122Hz como estándar y 1120 Hz como objetivo. Los datos tuvieron como referencia separadamente a la punta de la nariz, la mastoides ipsilateral y el promedio matemático de las dos mastoides. Se determinó la presencia de respuesta según los estrictos criterios establecidos a priori. La correspondencia entre los hallazgos de MMN y el comportamiento paralelo de la discriminación de datos no fue sistemática. El invertir electrodos tuvo efecto en la presencia de MMN. Fue más probable que se presentaran MMN en la condición de referencia de datos a la mastoides que a la nariz. Por lo tanto cuando se usa este paradigma se sugiere la referencia a la mastoides para optimizar la detección de la respuesta MMN.

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