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Natural Product Research

Formerly Natural Product Letters
Volume 35, 2021 - Issue 21
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Brief Report

Chemosystematic evaluation of Amazonian freshwater sponges

ORCID Icon, , , , , & show all
Pages 4192-4196
Received 16 Jan 2020
Accepted 04 Apr 2020
Published online: 14 Apr 2020

Abstract

Freshwater sponges can be considered a promising new source of bioactive compounds for the pharmaceutical industry; however, the research on their chemical composition is still in the incipient stage. We evaluated the most endemic Amazonian freshwater sponge species from the Drulia and Metania genera by untargeted metabolomic approaches, based on UHPCL-HRMS, in order to identify chemical markers and explore the diversity of specialized metabolites. The use of untargeted approaches allowed us to observe subsets of metabolites that enabled the characterization of, not only each genus, but also, of each species. Freshwater sponge species presented themselves as rich sources of fatty acids and sterols, which were putatively identified. These metabolites were suggested as chemical markers for further targeted metabolomic studies.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The authors wish to give thanks to the Brazilian financial agencies FAPEAM, CNPq (Grant no 306156/2015-6 – TCCF), FAPERJ (Grant no E-02/202.961/2017–TCCF), CAPES (Pos-Doctoral fellowship of JAL) and FINEP. This work was also supported by the FIM excellence project.

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