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Abstract
A phytochemical investigations on the n-butanol fraction of Lavandula angustifolia Mill. residues resulted in the isolation of ten compounds, including two new ones, 4,4′dimethoxy-2,2′di-O-β-d-glucopyranosyl-truxinate (1) and 2-(β-d-glucosyloxy)-trans-cinnamic acid butyl ester (2), along with eight known compounds. The structures of compounds were confirmed by NMR and HR-ESI-MS techniques and comparison with published data. The NMR data for 3 were attributed for the first time. Compound 2 was proofed to be a natural compound in plant rather than a butyl ester artifact formed by esterification reaction with butanol by comparative HPLC-DAD analysis with the ethanol extract which was obtained prior to the application of butanol. All isolated compounds were evaluated for their antioxidant and anti-hypoglycaemic activities. Among them, compounds 4 and 5 showed strong anti-oxidant activities against DPPH with IC50 values of 12.99 and 31.74 μM, respectively. Compound 5 exhibited moderate inhibitory activity against PTP1B with an IC50 value of 31.28 μM.
Graphical Abstract
Published online:
01 November 2019![Graphical abstract]({"type":"image","src":"/na101/home/literatum/publisher/tandf/journals/content/gnpl20/2021/gnpl20.v035.i15/14786419.2019.1684283/20210810/images/medium/gnpl_a_1684283_uf0001_c.jpg"})
Disclosure statement
No potential conflict of interest was reported by the authors.