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Abstract
Lactoquinomycin C (1) and Lactoquinomycin D (2), two new medermycin derivatives together with six known compounds (3–8) were isolated from the rice solid fermentation of the marine-derived Streptomyces sp. SS17A. The intriguing structural features of the Lactoquinomycin D (2) which contains 5,14-epoxidation is relatively rare in medermycin derivatives. Compounds 1 and 2 exhibited no cytotoxicity against PC-3 and HCT-116 cancer cell lines, whereas compound 3 showed stronger cytotoxicity with IC50 values of 0.02 and 0.04 μM, respectively. A structure-activity relationship was observed for the cytotoxicity of the medermycin derivatives with a γ-lactone unit is required for significant cytotoxicity based on compounds 1–3.
Graphical abstract
Disclosure statement
No potential conflict of interest was reported by the author(s).
Published online:
26 February 2019Figure 1. Structures of isolated compounds (1–8).
![]({"type":"image","src":"/na101/home/literatum/publisher/tandf/journals/content/gnpl20/2020/gnpl20.v034.i09/14786419.2018.1556265/20200416/images/medium/gnpl_a_1556265_f0001_b.jpg"})
Figure 1. Structures of isolated compounds (1–8).