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Natural Product Research

Formerly Natural Product Letters
Volume 33, 2019 - Issue 21
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Research Articles

Centaurea microcarpa Coss. & Dur. (Asteraceae) extracts: New cyanogenic glucoside and other constituents

, , ORCID Icon, , , , , , & show all
Pages 3070-3076
Received 30 Apr 2018
Accepted 26 Aug 2018
Published online: 16 Nov 2018

Samia Baatouchea, Thamere Cherietab, Djamel Sarric , Ratiba Mekkioua, Ouahiba Boumazaa, Samir Benayachea, Fadila Benayachea, Ignacio Brouardd, Francisco Leónd & Ramdane Seghiria*

a Unité de recherche Valorisation des Ressources Naturelles, Molécules Bioactives et Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université des Frères Mentouri Constantine, Constantine, Algérie;

b Département de chimie, Faculté des sciences, Université Mohammed Boudiaf-M’sila, M’sila, Algérie;

c Département de Biologie, Faculté des sciences, Université Mohammed Boudiaf-M’Sila, M’Sila, Algérie;

d Instituto de Productos Naturales y Agrobiología-CSIC, Instituto Universitario de Bio-Orgánica ‘Antonio González’, Universidad de La Laguna, La Laguna, Tenerife, Spain

Supplemental data for this article can be accessed at https://doi.org/10.1080/14786419.2018.1517343.

CONTACT Ramdane Seghiri

Abstract

The phytochemical investigation of both chloroform and ethyl acetate extracts of Centaurea microcarpa Coss. & Dur. led to the isolation of a new cyanogenic glucoside 6'-methacrylate prunasin (3) together with seven known compounds: hydroxy-11β,13-dihydro onopordaldehyde (1), β-sitosterol (2), daucosterol (4), nepetin (5), prunasin (6), astragalin (7) and 7-O-β-D-glucopyranosyl centaureidin (8). Their structures were established by spectral analysis, mainly UV, IR, ESI-MS, 1D & 2D-NMR experiments (COSY, HSQC, HMBC and ROESY).

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