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Abstract
Introduction: In women, bone mineral density (BMD) is related to age, estrogenic action, and appendicular skeletal muscle mass (ASMM). The gynoid fat distribution is linked to estrogenic action.
Objective: This study aimed to assess whether an increase of gynoid fat is associated with high BMD independent of age and ASMM.
Methods: An observational study was performed in women aged between 20 and 79 years. Fat mass, ASMM, and BMD were measured with dual-energy X-ray absorptiometry. The binned scatterplots and multivariate linear regression models were used to study the relationship between hip BMD and age, height, android fat, gynoid fat, and ASMM.
Results: Of 673 women invited, 596 accepted to participate. Their mean age was 55.4 ± 12.8 years, weight 63.4 ± 9.4 kg, height 1.61 ± 0.06 m, body mass index 24.54 ± 3.59 kg/m2, average hip BMD 0.914 ± 0.122 g/cm2, android fat 2.12 ± 0.83 kg, gynoid fat 4.54 ± 1.07 kg, and ASMM 15.15 ± 1.97 kg. The final regression model included age (linear coefficient −0.004; 95% confidence interval [CI]: −0.005 to −0.003; p < 0.001), ASMM (linear coefficient 0.013; 95% CI: 0.009 to 0.018; p < 0.001), and gynoid fat (linear coefficient 0.013; 95% CI: 0.005 to 0.022; p < 0.002).
Conclusion: Gynoid fat is associated with BMD in the hip independently of age and ASMM.
引言：女性的骨密度（BMD）与年龄、雌激素作用和四肢骨骼肌质量（ASMM）相关。女性脂肪分布与雌激素的作用相关。
目的：本研究旨在评估女性脂肪的增加是否与高BDM相关且独立于年龄和ASMM。
方法：研究纳入年龄在20-79岁的女性。用双能X线吸收法测量脂肪量、ASMM和BMD。采用分类散点图和多元线性回归模型研究髋部BMD与年龄、身高、男性型脂肪、女性型脂肪和ASMM之间的关系。
结果：673名女性符合纳入条件, 596名同意参加研究。平均年龄为 55.4±12.8岁, 体重 63.4±9.4kg, 身高1.61±0.06m, 体重指数24.54±3.59kg/m2, 平均臀部骨密度为0.914±0.122g/cm2, 男性型脂肪为2.12±0.83kg, 女性型脂肪为4.54±1.07kg以及ASMM为15.15±1.97kg。最终回归模型包括年龄（线性系数0.004；95%的置信区间[CI]：0.005-0.003；p<0.001）, ASMM（线性系数0.013；95%CI:0.005-0.022; p<0.002）
结论：女性型脂肪与髋部BMD相关, 与年龄和ASMM无关。
Potential conflict of interest
The authors report no conflicts of interest and are responsible only for the content and writing of this article.
Source of funding
Nil.