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ABSTRACT
Introduction
Six patients with equivocal amyloid-PET results are discussed.
Methods
Patients underwent clinical/neuropsychological assessment, MRI, and amyloid-PET. Equivocal amyloid-PET was defined as cortical ligand binding with SUVR < 1.40. Follow-up for up to 5 years is presented.
Results
6 patients (4 males, 2 females, mean age 71.8 +/- 2.5 years) with equivocal amyloid-PET were included from 136 patients who underwent amyloid-PET (4.4% of cases). Patients had variable language, behavioral, and cognitive deficits. Progression varied from no deterioration to residential care within 3 years.
Discussion
Equivocal amyloid-PET should be interpreted cautiously. Improved biomarkers of AD and other neurodegenerative diseases are needed.
Acknowledgments
This work was supported in part by funding to Forefront, a collaborative research group dedicated to the study of frontotemporal dementia and motor neuron disease, from the National Health and Medical Research Council of Australia (NHMRC) program grant (#1037746) and the Australian Research Council Centre of Excellence in Cognition and its Disorders Memory Program (#CE110001021). We are grateful to the research participants involved with the ForeFront research studies. JRB was supported by an NHMRC Early Career Fellowship (#1072451). CEL is supported by an NHMRC-ARC Dementia Development Fellowship (#1102969). OP is supported by an NHMRC Senior Research Fellowship (#1103258).
Disclosure statement
No potential conflict of interest was reported by the authors.