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ABSTRACT

Having the ability to work with complex models can be highly beneficial. However, complex models often have intractable likelihoods, so methods that involve evaluation of the likelihood function are infeasible. In these situations, the benefits of working with likelihood-free methods become apparent. Likelihood-free methods, such as parametric Bayesian indirect likelihood that uses the likelihood of an alternative parametric auxiliary model, have been explored throughout the literature as a viable alternative when the model of interest is complex. One of these methods is called the synthetic likelihood (SL), which uses a multivariate normal approximation of the distribution of a set of summary statistics. This article explores the accuracy and computational efficiency of the Bayesian version of the synthetic likelihood (BSL) approach in comparison to a competitor known as approximate Bayesian computation (ABC) and its sensitivity to its tuning parameters and assumptions. We relate BSL to pseudo-marginal methods and propose to use an alternative SL that uses an unbiased estimator of the SL, when the summary statistics have a multivariate normal distribution. Several applications of varying complexity are considered to illustrate the findings of this article. Supplemental materials are available online. Computer code for implementing the methods on all examples is available at https://github.com/cdrovandi/Bayesian-Synthetic-Likelihood.

Acknowledgments

LFP and CCD are grateful to Mat Simpson for assistance with the cell biology example. CCD thanks NUS and the University of Warwick for supporting a visit where discussions on this research took place. LFP was supported by an Australian Postgraduate Award. CCD was supported by an Australian Research Council’s Discovery Early Career Researcher Award funding scheme DE160100741. DJN was supported by a Singapore Ministry of Education Academic Research Fund Tier 2 grant (R-155-000-143-112).

Supplementary Materials

Additional information to supplement the main article is available in the following files found online.

  • Appendices: Contains all appendices to the main document. (Appendices.pdf, PDF portable document format)

  • Code: Contains all of the code required to perform the described methods on the Ricker example from Section 4.2. (Code.zip, compressed (zipped) folder)

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