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https://orcid.org/0000-0002-0236-1606
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Abstract
OSMAC approach was performed on the soft coral-derived fungus Trichoderma harzianum (XS-20090075) leading to the significant changes of its secondary metabolites by using two different cultures. A new naphthalene derivative, trichoharzin B (1) and a new natural product, methyl-trichoharzin (2) were isolated by using rice medium. Whereas, a new natural product, ethyl 2-bromo-4-chloroquinoline-3-carboxylate (9) was obtained by using Czapek’s medium. Their structures were established by extensive spectroscopic investigation. The absolute configuration of 5 was determined by single-crystal X-ray diffraction. Compound 9 was the first halogenate quinoline derivative isolated from the genus of Trichoderma.
Graphical Abstract
![Graphical abstract]({"type":"image","src":"/na101/home/literatum/publisher/tandf/journals/content/ganp20/2021/ganp20.v023.i03/10286020.2020.1729752/20210402/images/medium/ganp_a_1729752_uf0001_c.jpg"})
Disclosure statement
No potential conflict of interest was reported by the authors.
Supplementary material
Supplementary material relating to this article is available online, NMR, single-crystal and MS data for 1, 2, 5 and 9.