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Abstract
Abstract
Six new indole alkaloid diglycosides named isatigotindolediosides A-F (1–6), along with three known analogs (7–9), were isolated from an aqueous extract of the Isatis indigotica roots (ban lan gen). Their structures including the absolute configurations were determined by comprehensive spectroscopic data analysis, combined with enzyme or acid hydrolysis, and comparison of experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra. In the preliminary assays, compounds 3, 5, and 8 showed antiviral activity against Coxsackie virus B3.
![Graphical abstract]({"type":"image","src":"/na101/home/literatum/publisher/tandf/journals/content/ganp20/2017/ganp20.v019.i06/10286020.2017.1320547/20170523/images/medium/ganp_a_1320547_uf0001_oc.jpg"})
Acknlowledgements
We thank Chinese Academy of Medical Sciences and Peking Union Medical College High Performance Computing Platform for supporting the calculation of the ECD spectra.