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Abstract
Four new dianthrone glycosides, named polygonumnolides C1-C4 (1–4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5–6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1–4 showed weak hepatotoxicity against L-02 cell lines with IC50 values of 313.05, 205.20, 294.20, and 207.35 μM, respectively.
Acknowledgments
The authors are grateful to the members of the analytical group for measuring the spectroscopic data (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China). We also thank Yu Wu (National Institutes for Food and Drug Control, State Food and Drug Administration, Beijing 100050, China) for the hepatotoxicity assays.