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Abstract
Objective
This study aimed to observe the changes in serum vaspin levels in pregnant women after glucose load during oral glucose tolerance test (OGTT) and analyze the effect of blood glucose levels on serum vaspin secretion in pregnant women with gestational diabetes mellitus (GDM).
Methods
It included 30 patients with GDM and 30 age-matched pregnant women with normal glucose tolerance (NGT, control). The blood glucose, insulin, total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), and serum vaspin levels were measured at 24–28 weeks of gestation. The homeostasis model assessment of insulin resistance (HOMA-IR) values were calculated.
Results
1. The levels of fasting plasma glucose (FPG), 1-h PG, 2-h PG, fasting insulin (FINS), HOMA-IR, baseline vaspin, 1-h vaspin, and 2-h vaspin were higher in the GDM group than in the NGT group. 2. The 1-h and 2-h vaspin levels were significantly higher than the baseline levels in the GDM group. The change in the vaspin level after 1 h in the GDM group during the OGTT was significantly greater than that in the NGT group. 3. The vaspin levels in the GDM group positively correlated with 1-h PG and TG, including the baseline vaspin (r = 0.494, p = .006; r = 0.385, p = .036), 1-h vaspin (r = 0.577, p = .001; r = 0.466, p = .010), and 2-h vaspin (r = 0.557, p = .001; r = 0.488, p = .006).
Conclusion
Vaspin might be regulated by the hyperglycemia level and involved in the pathogenesis of GDM and lipid metabolism.
目的：通过口服葡萄糖耐量试验（OGTT）观察孕妇糖负荷后血清丝氨酸蛋白酶抑制剂（vaspin）水平的变化, 分析血糖水平对妊娠糖尿病（GDM)孕妇血清Vaspin分泌的影响。
方法：纳入30例GDM患者和30例年龄匹配、糖耐量正常（NGT, 对照组）的孕妇。测定妊娠24-28周的血糖、胰岛素、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和血清vaspin水平。计算胰岛素抵抗指数（HOMA-IR）。
结果：1.GDM组空腹血糖（FPG）、1-h PG、2-h PG、空腹胰岛素（FINS）、HOMA-IR、基线vaspin、1-h vaspin、2-h vaspin水平明显高于NGT组。2.GDM组1-h、2-h vaspin水平明显高于基线水平。GDM组在OGTT试验过程中, 1h后的vaspin水平的变化明显大于NGT组。3.GDM组vaspin水平与1-h PG、TG呈正相关, 包括基线vaspin （r=0.494, p=0.006; r=0.385, p=0.036）, 1-h vaspin (r=0.577, p=0.001; r=0.466, p=.010), 和2-h vaspin (r=0.557, p=0.001; r=0.488, p=0.006)。
结论：Vaspin可能受高血糖水平的调节, 参与GDM的发病机制及脂代谢。
Acknowledgments
The authors acknowledge the help of all the medical staff at the Hebei General Hospital.
Disclosure statement
No potential conflict of interest was reported by the author(s).