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Abstract
Cross-linked polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) composite nanofibrous membranes have been prepared by electrospinning. Mechanical properties of the membranes improved significantly with PVP addition. PVP improved hydrophilicity and sustainable degradation of the membranes. Biocompatibility of the membranes was assessed by in vitro culture of native skin cells (L929 fibroblast and HaCaT keratinocytes). Tests showed sustained release of the antibiotic ciprofloxacin hydrochloride monohydrate by the membranes. Further, zone of inhibition study against Staphylococcus aureus growth demonstrated protective action against external pathogenic microbes. These studies show these simple PVA–PVP nanofibrous membranes are promising interactive antibiotic-eluting wound dressing materials.
Acknowledgments
We are grateful to Department of Atomic Energy (2010/34/54/BRNS), Department of Biotechnology (BT/505/NE/TBP/2013 and BT/IN/Sweden/38/BBM/2013) and Department of Science and Technology (SB/FT/LS-213/2012), Government of India, for financially supporting this work. High end instrument support received from Central Instruments Facility, IIT Guwahati is gratefully acknowledged.
Disclosure statement
No potential conflict of interest was reported by the authors.