The nuclear negotiations between Iran and EU3+3 have provided the grounds for establishing direct talks between Iran and the United States, subsequently creating a positive prospect for solving the Iranian nuclear standoff after a decade of negotiations. The effect of economic sanctions and political change in Iran have made it possible to bring an important foreign policy issue into domestic politics discourses. The fact that the nuclear negotiations put Iran in a position comparable to the other world powers strengthened a sense of movement towards a win-win situation among Iranian political forces. All of this created a relative political consensus among Iran’s ruling elites regarding the need to initiate direct talks with the United States in order to solve the Iranian nuclear standoff. The nuclear programme is also linked with the regional equation, the result of which has been the emergence of a new kind pragmatism in the conduct of Iranian regional policy in hope of revising Iran’s place in US Middle East policy.