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ABSTRACT
Purpose of the study
To assess differences in healthy eyes in volume (CV) and choroidal thicknesses (CT) across all macular Early Treatment Diabetic Retinopathy Study (ETDRS) areas measured by swept source (SS)-OCT and spectral domain (SD)-OCT with enhanced depth imaging (EDI).
Materials and Methods
One hundred and fifty healthy eyes were studied in patients aged between 21–68 years. All of these patients underwent an ophthalmic examination that included axial length (AL), a fast macula protocol with EDI by Spectralis SD-OCT, and a 3D macular cube by DRI-Triton SS-OCT. CT and CV values were measured after a manual segmentation with SD-OCT and automatically with SS-OCT.
Results
The values obtained by SD-OCT were statistically higher than the values obtained by SS-OCT in all ETDRS areas. To determine the differences that were related to total CV or AL, the eyes were divided depending on their total CV and AL values into two groups. There were persistent differences between the two devices that were not related to the total CV. In subjects with a higher AL, these differences were not present in either the total CV or the subfoveal CT. In longer eyes, the differences diminished, and there were no statistical differences between the devices in the subfoveal area, temporal quadrants, inferior inner ring, or CV.
Conclusions
The choroidal values obtained with the SD-OCT are statistically higher than those measured by SS-OCT. Both techniques are able to clearly visualize the choroidoscleral interface and provide different values that are highly correlated. These differences are smaller in eyes with a longer AL and are not related to the total CV.
Acknowledgments
The authors thank the patients in this study and colleagues contributions.
Declaration of interest statement
The authors report no conflicts of interest and have no proprietary interest in any of the materials mentioned in this article.
Authorship
I.P. designed the research. E.O.H. and L.P. recruited the control and diabetic subjects and performed the experiments. A.S.C. and E.O.H did the statistical calculations, made tables and critically reviewed the manuscript. I.B. and G.I. critically reviewed the manuscript for important intellectual content, reviewed the data and the SD-OCT images. I.P. did the eye fundus examinations. I.P and E.O.H. wrote the manuscript. All authors gave final approval of the version of the manuscript to be submitted and any revised version. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted.