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Acta Oto-Laryngologica

Volume 140, 2020 - Issue 9
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Larynx

Risk factors for aggressive recurrent respiratory papillomatosis in Chinese juvenile patients

Yue Xi Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; ; Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; ; Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; View further author information
,
Hua Wang Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; View further author information
,
Wei Wang Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; ; Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; ; Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; View further author information
,
Xiaolin Wang Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; ; Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; ; Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; View further author information
,
Jie Zhang Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; View further author information
,
Jing Zhao Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; View further author information
,
Guixiang Wang Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; View further author information
,
Jingang Gui Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; ; Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; ; Beijing Key Laboratory for Genetics of Birth Defects, MOE Key Laboratory of Major Diseases in Children, Center for Medical Genetics, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; Correspondenceguijingang@bch.com.cn
View further author information
&
Xin Ni Key Laboratory of Major Disease in Children, Ministry of Education, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; ; Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; ; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaCorrespondencenixin@bch.com.cn
View further author information
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Pages 771-776
Received 16 Mar 2020
Accepted 05 May 2020
Published online: 03 Jun 2020
 
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Abstract

Abstract

Background: Aggressive juvenile-onset recurrent respiratory papillomatosis (JORRP) threatens patient lives if not receives immediate surgical intervene. Even with surgical intervene, complete remission of this disease is not approachable. Therefore, understanding the factors relevant to disease severity and prognosis will do help to the treatment strategy and health management of this disease.

Objective: This study aimed to explore the clinic, laboratory and socioeconomic characteristics of patients and evaluate the risk factors for aggressive JORRP.

Methods: The information of clinical and socioeconomic status of the patients was reviewed and its association with disease severity was analyzed. Papilloma from JORRP patients undergone surgeries was used to determine HPV subtypes by real-time PCR. The profiles of mRNA expression in the papilloma were assessed using microarray.

Results: Age at diagnosis and socioeconomic status were shown to associate with the severity of JORRP. There was no differential severity considering different HPV subtype. The mRNA expression of nucleotide binding oligomerization domain receptor protein 3 (NLRP3) and Gasdermin B (GSDMB) was reduced in papillomas.

Conclusions: A younger age at diagnosis and low socioeconomic status were associated with the severity of JORRP. mRNA expression of NLRP3 and GSDMB in the papillomas of JORRP patients was significantly reduced.

  • Abbreviation: JORRP: Juvenile-onset recurrent respiratory papillomatosis; RRP: Recurrent respiratory papillomatosis; OSAS: Obstructive sleep apnea syndrome; NLRP3: Nucleotide binding oligomerization domain receptor protein 3; GSDMB: Gasdermin B.

Chinese abstract

背景：侵袭性青少年复发性呼吸道乳头状瘤病（JORRP）如果不立即接受外科治疗, 将威胁患者的生命。即使通过手术干预, 这种疾病的完全缓解也是不可取得的。因此, 了解与疾病严重程度和预后相关的因素, 将有助于该病的治疗策略和健康管理。

目的：探讨侵袭性JORRP患者的临床、实验室及社会经济学特点, 探讨其危险因素。

方法：回顾性分析患者的临床和社会经济状况, 分析其与疾病严重程度的关系。接受手术的JORRP患者的乳头状瘤用于通过实时聚合酶链反应（real-time PCR）来检测HPV亚型。应用微阵列技术检测乳头状瘤组织中mRNA的表达。

结果：诊断年龄和社会经济状况与JORRP的严重程度有关。鉴于不同的HPV亚型, 严重程度无分异。乳头状瘤中核苷酸结合寡聚结构域受体蛋白3（NLRP3）和气皮蛋白 B（GSDMB）的mRNA表达降低。

结论：较小的诊断年龄及较低的社会经济地位与JORRP的严重程度相关。JORRP患者的乳头状瘤中NLRP3和GSDMB的mRNA表达明显降低。

Disclosure statement

The authors claim no conflict of interest.

Additional information

Funding

This study was supported by a grant from National Natural Science Foundation of China [81970867].

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