To investigate the possible role of vasopressin (VP) in the maintenance of DOC-salt hypertension the effect of two VP pressor antagonists on mean arterial pressure and the pressor responsiveness to exogenous VP were studied in conscious, freely moving rats with malignant DOC-salt hypertension. Intravenous injections of either 20 μg/kg of dP Tyr(Me)AVP or 10 μg/kg of d(CH2)5 Tyr(Me)AVP had no significant effect on mean arterial pressure and heart rate, although both antagonists almost completely abolished the pressor response to VP. Furthermore, the animals with DOC-salt hypertension exhibited decreased pressor responsiveness to exogenous VP. The present findings strongly suggest that VP is not essential as a pressor hormone for maintaining blood pressure in malignant DOC-salt hypertension.
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Original Article
Evidence Against a Vasopressor Role of ADH in Malignant Doc-Salt Hypertension
J. Filep Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 7000, Stuttgart, Germany FRG
, J. C. Frölich Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 7000, Stuttgart, Germany FRG
, G. Fejes-Tóth Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 7000, Stuttgart, Germany FRG
& B. Rigter Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 7000, Stuttgart, Germany FRG
Pages 1457-1470
Accepted 15 Aug 1985
Published online: 03 Jul 2009
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Original Article
Evidence Against a Vasopressor Role of ADH in Malignant Doc-Salt Hypertension
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