The density of muscarinic receptor sites, choline acetyltransferase (ChAT), and aceytlcholinesterase (AChE) activity in the myocardium of the Dahl salt-sensitive (DS) and salt-resistant (DR) rat was investigated. Both normotensive and hypertensive (as a result of 8.0% NaCl added to the diet) DS rats displayed a lower concentration of muscarinic receptors and less ChAT and AChE activity in myocardial tissue than normotensive DR rats. Lower receptor site density and enzyme activity in the myocardial of the DS line may reflect decreased vagal tone. If true, this may produce deficits in the ability to appropriately adjust heart rate (HR) in response to elevations in blood pressure (BP). Therefore, the present results may be viewed as exacerbational factors in the pathogenesis of hypertension in the DS line.
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Original Article
Myocardial Cholinergic Receptor Sites and Enzyme Activity in the Dahl Model of Essential Hypertension
James A. McCaughran Department of Psychiatry and Behavioral Science, Health Sciences Center State University of New York, Stony Brook, New York, 11794
, Emmeline Edwards Department of Psychiatry and Behavioral Science, Health Sciences Center State University of New York, Stony Brook, New York, 11794
, Richard Friedman Department of Psychiatry and Behavioral Science, Health Sciences Center State University of New York, Stony Brook, New York, 11794
& Nisson Schechter Department of Psychiatry and Behavioral Science, Health Sciences Center State University of New York, Stony Brook, New York, 11794
Pages 811-826
Published online: 03 Jul 2009
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Original Article
Myocardial Cholinergic Receptor Sites and Enzyme Activity in the Dahl Model of Essential Hypertension
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