We have confirmed the presence of adrenal renin and have shown that the concentration is much higher in the glomerulosa cells. The renin concentration of these cells is influenced by changes in sodium balance and after nephrectomy, while the renin of the fasciculata-medullary tissue is not. There is a positive correlation between adrenal renin and aldosterone concentration. The data suggest that adrenal renin may be a local hormone that plays a role in the regulation of aldosterone production.