Steroid receptors were determined by the dextran-coated charcoal method in 193 breast cancer patients in different clinical stages of disease. Quantitative estrogen and progesterone values in primary tumors (n = 69) were compared with receptors in regional lymph node metastases (n = 28) and in distant malignant deposits (n = 65). The groups including receptor values from primaries and regional lymph node metastases (n = 15) and from primaries and distant metastatic lesions (n = 16) in the same patients were also analyzed. The obtained results indicated relative stability of both receptors in loco-regional disease, but with a tendency towards lower receptor values in lesions from advanced disease. This tendency is probably caused by the disease progression itself, but the influence of radio-or chemotherapy cannot be excluded.