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Abstract
[U-14C]-dimethylamine hydrochloride was administered by gavage (20 μmol/kg body weight) to adult male Wistar rat and CD1 strain mouse.
2. In both species, urine was the main route of excretion with the majority of radiolabel (91%) being voided during the first day. Additional small amounts of radioactivity were detected in the 24–72h urine (2%), in faeces (2%) and amidst exhaled air (1%), with minor amounts remaining within the carcass (1%) after 3 days.
3. Metabolism was limited to demethylation, with the majority of the compound (89% dose; 96% urinary radioactivity) being excreted unchanged.