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Scandinavian Journal of Gastroenterology

Volume 29, 1994 - Issue 7
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Original Article

Serologic Characteristics in Primary Biliary Cirrhosis Associated with Sicca Syndrome

T. Dörner Dept. of Medicine III and Institute of Medical Immunology, Medical School (Charité), Humboldt University of Berlin, Berlin, Germany; Dept. of Medical and Physical Therapy, University of Tokyo, Tokyo, Japan
,
C. Held Dept. of Medicine III and Institute of Medical Immunology, Medical School (Charité), Humboldt University of Berlin, Berlin, Germany; Dept. of Medical and Physical Therapy, University of Tokyo, Tokyo, Japan
,
G. Trebeljahr Dept. of Medicine III and Institute of Medical Immunology, Medical School (Charité), Humboldt University of Berlin, Berlin, Germany; Dept. of Medical and Physical Therapy, University of Tokyo, Tokyo, Japan
,
A. Lukowsky Dept. of Medicine III and Institute of Medical Immunology, Medical School (Charité), Humboldt University of Berlin, Berlin, Germany; Dept. of Medical and Physical Therapy, University of Tokyo, Tokyo, Japan
,
K. Yamamoto Dept. of Medicine III and Institute of Medical Immunology, Medical School (Charité), Humboldt University of Berlin, Berlin, Germany; Dept. of Medical and Physical Therapy, University of Tokyo, Tokyo, Japan
&
F. Hiepe Dept. of Medicine III and Institute of Medical Immunology, Medical School (Charité), Humboldt University of Berlin, Berlin, Germany; Dept. of Medical and Physical Therapy, University of Tokyo, Tokyo, Japan
Pages 655-660
Received 09 Mar 1993
Accepted 23 Nov 1993
Published online: 08 Jul 2009
 
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Original Article

Serologic Characteristics in Primary Biliary Cirrhosis Associated with Sicca Syndrome

Abstract

Dorner T, Held C, Trebeljahr G, Lukowsky A, Yamamoto K, Hiepe F. Serologic characteristics in primary biliary cirrhosis associated with sicca syndrome. Scand J Gastroenterol 1994;29:655-660

Background: Patients with primary biliary cirrhosis (PBC) may have coincidental sicca syndrome (SS). The frequencies of SS and the occurrence of the Sjögren's-associated anti-Ro and -La antibodies in PBC patients have been reported at widely varying prevalences. This study investigated whether distinctive serologic characteristics are associated with SS in PBC.

Methods: Forty PBC patients and thirty patients with other types of liver cirrhosis were tested for SS and associated autoantibodies (ANA, AMA 2, anti-Ro, anti-La, anti-U1RNP-A, -C, -68 kD, and rheumatoid factors).

Results: Fourteen PBC patients (35%) complained of sicca symptoms, of whom 10 (25%) had a positive Schirmer-I test, and 7 (17.5%) had serologic characteristics similar to those of Sjögren's syndrome. Anti-52-kD Ro antibodies were positive in seven PBC/SS cases (p < 0.025). There was no anti-Ro positive PBC patient without SS. Three patients with PBC/SS with anti-52-kD Ro and anti-smooth-muscle antibodies developed lung fibrosis. No patient in the other cirrhosis group had SS or its characteristic autoantibody findings.

Conclusions: It was suggested that PBC and SS are frequently associated. Anti-52-kD Ro antibodies seem to be a characteristic serologic finding for SS in PBC, suggesting their pathogenic role in autoimmune sialadenitis.

 

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