Chang FY, Lai KH, Wang TF, Lee SD, Tsai YT, Tsay SH. Location and type of gastric carcinoma in relation to pepsinogen 1 level in blood. Scand J Gastroenterol 1992;27:884-888.

Serum pepsinogen I (PGI) levels were measured in 192 gastric carcinoma (GC) patients and 70 controls. Among GC patients serum PGI levels were not influenced by the following variables: age, sex, smoking, Borrmann's or Lauren's classification, tumor size, cellular differentiation, and layer of invasion. The mean scrum PGI levels of tumors restricted to the body, antrum, or involving both areas were 64.8 ± 37.6ng/ml, 76.0 ± 47.0ng/ml, and 51.1 ±25.5ng/ml, respectively (P< 0.005). Odds ratios of GC patients from the quartile of 262 serum PGI levels in the limits s 100 ng/ml, 70-99.9 ng/ml, 45-69.9 ng/ml, and <45 ng/ml were 1.00, 0.76, 3.44, and 37.1, respectively (F < 0.001). The lower serum PGI levels of Chinese GC patients seem to be related to disease location rather than other characters of the tumor.