There have been several long term studies (>4 weeks) of cisapride in a variety of gastroparetic conditions. All of these studies have used cisapride lOmg t.i.d. or q.i.d.

Chronic idiopathic dyspepsia

Cisapride has been shown to be effective in both improving symptoms and also delayed gastric emptying in a six week study. In another placebo controlled study of two weeks, gastric emptying was improved but symptoms did not improve significantly.

Diabetic gastroparesis

In a four week study, cisapride has been shown to be effective in improving symptoms and solid phase gastric emptying. A six weeks study demonstrated both improvement of solid and liquid gastric emptying and symptoms.

Progressive systemic sclerosis

Cisapride was effective in improving symptoms over a four week period. Myotonic dystrophy

Combined studies

Cisapride was effective in improving solid phase gastric emptying and symptoms over a four week period.

Combined studies

In two combined studies, cisapride has been shown to be effective in a variety of gastroparetic conditions.

One year studies

In three open long term studies, cisapride appears to be the first prokinetic agent to demonstrate long term efficacy for up to one year.