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Abstract
Aims: To evaluate the relation between high methadone doses and methadone serum levels in MMT patients.
Design:One hundred fifty-one steady methadone-dose patients were evaluated for methadone serum levels using GCMS. Urine samples during the month prior to the study-day were analyzed and defined as positive if any sample was positive for any drug.
Findings:Methadone dose correlated with methadone serum levels (Pearson R = 0.36, p < 0.0005). In 53 patients with no drug abuse, correlation was stronger (R = 0.53, p < 0.0005) than in 98 patients with any drug abuse (R = 0.25, p = 0.01).
Conclusions:We extended the well-established correlation between methadone doses and serum levels in patients receiving low or moderate (60 to 120 mg/day) to high methadone doses (up to 290 mg/day)