Climate change continues to threaten the lives and livelihoods of small farmers of Nepal. Given the importance of Nepal's agriculture to the nation's economy, potential impacts of climate variability and change on national food security is a cause for concern. Notwithstanding this challenge, efforts are being made to identify the climate-change impacts on agriculture and actions that farmers and their supporting institutions can take to adapt. The repository of local agro-ecological knowledge available across Nepalese communities is worth exploring. This study, through analysis of four examples of innovative agricultural practices – referred to here as niche-based, details the responses of farmers and their supporting institutions to climatic limitations in Nepal. We identify and synthesize commonalities of the four case studies that may be integral to climate-change adaptation as: (1) the need for participation, flexibility and integration of all stakeholders in the process of innovating adaptation technologies; and (2) the potential for farmers (end-users) and their supporting institutions to take on more leadership and responsibility to sustain the effectiveness of adaptation measures.