The International Organization for Standardization (ISO) is currently voting on a final draft of ISO 14000 Environmental Standards that follow the general philosophy of ISO 9000 product quality standards. Should the international community also consider development of an ISO 9000-14000 compatible occupational safety and health management standard (OS&HMS) or an environment, safety, and health management standard? The first paper in this series (Am. Ind. Hyg. Assoc. J. 56:599–609 [1995]) introduced this subject, reviewed the historical precedents, and identified the underlying issues. In this paper the authors identify some of the potential benefits and most critical open issues that may affect the viability of an OS&HMS at the national and international levels. Twelve potential benefits are identified in the major categories of national and international, and industrial and governmental benefits; 16 open issues are identified in the major categories of applications, ethics, cost, and international issues.