To assess the early cellular inflammatory response of the lungs, 7 rats per group were exposed nose‐only to 13 mg/m 3 of chrysotile asbestos, 7 h/day for 2, 4, or 6 wk. Lung histopathology and bronchoalveolar lavage (BAL) were analyzed. In exposed animals, dose‐related bronchiolitis and fibrosis were found that were not seen in control rats (p < 0.001). In exposed rats, total BAL cells were increased six‐ to sevenfold over matched controls, and more cells were retrieved with longer exposure (p < 0.001). In the BAL, counts of macrophages, lymphocytes, and polymorphonuclear cells (PMNs) were each elevated in the exposed rats (each p < 0.001). PMNs seen histologically and in the BAL may be related to the time period examined. PMNs and lymphocytes observed throughout this 6‐wk study support the idea that these cells may have an important role in the early events of asbestos lung injury.
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Journal of Toxicology and Environmental Health
Volume 20, 1987 - Issue 1-2
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Original Articles
Sequence of bronchoalveolar lavage and histopathologic findings in rat lungs early in inhalation asbestos exposure
Cecilia M. Smith Pulmonary and Critical Care Division, Department of Medicine , University of California, Pulmonary Division, UCSD Medical Center , H‐772, 225 Dickinson Street, San Diego, California, 92103
, Sharon Batcher Pulmonary and Critical Care Division, Department of Medicine , University of California , San Diego, California
, Antonino Catanzaro Pulmonary and Critical Care Division, Department of Medicine , University of California , San Diego, California
, Jerrold L. Abraham Department of Pathology, Upstate Medical Center , S.U.N.Y. , Syracuse, New York
& Robert Phalen Air Pollution Health Effects Laboratory, Department of Community and Environmental Medicine , University of California , Irvine, California
Pages 147-161
Received 27 May 1986
Accepted 26 Aug 1986
Published online: 19 Oct 2009
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Original Articles
Sequence of bronchoalveolar lavage and histopathologic findings in rat lungs early in inhalation asbestos exposure
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