We examined school sense of community (SSOC) between university students who are first-generation U.S. citizens (n = 936) or students who are non-first-generation U.S. citizens (n = 3,556), and between first-generation college students (n = 1,114) and students who are non-first-generation college students (n = 3,378), both attending an urban and diverse Roman Catholic university. Participants reported their SSOC and whether the school was innovative and inclusive, examining whether a higher sense of school community and positive notions of one's campus mission related to being a first-generation U.S. citizen or a first-generation college student. Results showed that a lack of belongingness may lead to lower academic achievement, school dropouts, and less school involvement. Future research should explore why there is a differing impact on school sense of community and campus mission perception for students who are first-generation U.S. citizens or first-generation college students.