Although leisure is held to provide positive health benefits, structural and social obstacles deny equal participation to the disenfranchised. Employing quantitative and unique qualitative (e.g., Photovoice) methods, we examined the leisure behaviors of older women who were living in the United States and diagnosed with HIV/AIDS. Findings pointed to differences in time for, access to, and meaning of leisure in pre- vs. post-infection leisure for these women. As the disease progressed, however, each woman exhibited resilience in transcending systemic barriers to derive a spiritual view of leisure as a metaphor for the meaning of life. We believe our findings of spiritual transcendence will resonate among people living with HIV/AIDS throughout both Western and non-Western cultures.