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Synthetic Communications

An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 37, 2007 - Issue 9
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Original Articles

Rapid Method of Converting Primary Amides to Nitriles and Nitriles to Primary Amides by ZnCl2 using Microwaves under Different Reaction Conditions

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Pages 1545-1550
Received 28 Sep 2006
Published online: 11 May 2007
 

Abstract

A rapid and facile method for the conversion of primary amides to nitriles using inexpensive and readily available ZnCl2 in aqueous acetonitrile and their regeneration using ZnCl2–H2O–THF in the presence of acetamide under microwave irradiation in good yields is reported. The reactions go to completion within a minute.

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