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Abstract
Abstract
1. The suitability of sodium nitroprusside (SNP) as a source of dietary cyanide has been tested with growing chicks and with hens by measuring plasma or urinary thiocyanate, the major detoxication product of cyanide.
2. Growth and food intake were depressed and plasma thiocyanate concentration was increased in chicks in a progressive manner as the dietary concentration of SNP was increased from 0 to 0.5 g/kg.
3. In laying hens, urinary excretion of thiocyanate was increased fivefold by including SNP in the diet at 0.3 g/kg.
4. It is concluded that SNP is a suitable and convenient source of dietary cyanide for the investigation of chronic cyanide toxicity.