The idea of ‘clean’ bombs, nuclear weapons with a reduced amount of radioactive fallout resulting from their fission part, has met much ridicule since its public inauguration in 1956. Many scholars have regarded the bombs as a propaganda tool, stopping short of analyzing their role in the transformative phase of US nuclear strategy in the 1950s. This paper reexamines the clean bomb episode through 1958, shedding light upon the dynamic relationship between the development of nuclear weapons technology and the evolution of nuclear strategy from massive retaliation to flexible response. It also discusses the mechanism and momentum of nuclear weapons technology innovation until the US suspended nuclear testing in late 1958.