In recent years there has been growing recognition of the militarisation of US foreign policy in Africa, especially following the establishment of a dedicated, regional combatant command (Africa Command, or AFRICOM) in 2007. At the same time knowledge of the extent and aims of US military activities in Africa remains murky, especially when compared to other regions such as the Middle East and Europe. This article begins by conceptualising AFRICOM as a geopolitical assemblage, an approach we believe useful for analysing its composition and emergence. Next we discuss the challenges involved in tracing the US military’s evolving presence in Africa and the methods utilised in our analysis. Following this we present three case studies: the first compares the composition and geographies of manned and unmanned aerial surveillance assemblages, the second details logistics infrastructures and the military’s use of contractors to develop logistical capabilities across the continent, the third examines growing counterterrorism entanglements in West Africa. We conclude with some observations concerning the divergence between purported aims and the focus and outcomes of the US military’s presence in Africa.