![Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days]({"type":"image" , "src" : "/sda/5944/TOC-Subject-Sample-2021-Medicine-Dentistry-Nursing-Allied-Health.jpg"})
Abstract
Objectives: Neurodegenerative diseases (NDs) such as Alzheimer Diseases (AD), Parkinson Diseases (PD) are a huge public health problem. The elucidation of their pathophysiological mechanism is one of our greatest challenges. Hyperactive immune system contributes to the pathophysiology of neurological disorders.
Methods: In this review article, we have highlighted the neurodegenerative role of CDK5 and its involvement in Amyloid precursor pathway via Beta secretase enzyme.
Results:All the landmark research reports for CDK5 were considered for this review and its involvement in disrupted autophagy and hyper immune response is the key cause for neurodegeneration.
Conclusion: In conclusion, the present review focus on the pathways associated with Cdk5 and its role in causing neurodegeneration.
Acknowledgement
The article has been written with the financial support of RUSA – phase 2.0 grant sanctioned wide letter no. F. 24-51/2014-U, Policy (TN Multi –Gen), Dept. of Edn. Govt. of India, Dt. 09.10.2018.
Disclosure statement
No potential conflict of interest was reported by the authors.