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Cloning, expression and immunogenicity of the avian pneumovirus (Colorado isolate) F protein
- DOI:
- 10.1080/03079450120078653
pages 471-474
Available online: 17 Jun 2010Abstract
The F protein of the Colorado isolate of avian pneumovirus (APV), expressed from a DNA plasmid, was recognized by antiserum to both A and B subgroup APVs. After two intramuscular injections of turkeys with this plasmid, a homologous antibody response was detected by enzyme-linked immunosorbent assay. This antibody also recognized subgroup A APV. However, there was no neutralization of the Colorado isolate or of subgroup A or B viruses. Although no significant clinical protection was detected following homologous challenge of poults, an anamnestic serological response was seen, suggesting that a systemic antibody response but no local mucosal immunity was induced.
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- Citation information:
- Available online: 17 Jun 2010
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- 2010 Impact Factor 1.967; Article Influence: 0.609 - Ranking: 16/145 (Veterinary Sciences)
- Published on behalf of the Houghton Trust
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